In the present study we found that anti-YghJ IgA from saliva and ALS had a clearly higher proportion of anti-YghJ IgA targeting the glycosylated epitopes than the intestinal IgA, and that the glycosylation specificity of anti-YghJ IgA in ALS seemed to correlate with those in serum. This evidence concerns the gene CD79A and amyotrophic lateral sclerosis.