We previously described that Dhps∆epi mice develop spontaneous colon inflammation and are highly susceptible to DSS colitis, notably due to the translation of enzymes involved in aldehyde detoxification and increased levels of electrophile adducts in CECs,26 a hallmark of gastrointestinal tissue damage.26,40–42 Interestingly, we confirmed in the present paper that DHPS in IECs supports the translation of proteins involved in detoxification of peroxides (THIO, PRDX6) and reactive aldehydes (ALDHs, GSTs) during C. rodentium infection. The gene discussed is HPGDS; the disease is colitis.