DHPS and colitis: We previously reported that infection with C. rodentium, the rodent equivalent of EPEC, which causes colitis in mice,11,35 leads to the induction of DHPS in colonic macrophages.24 Herein, we observed that the protein DHPS and the level of hypusinated EIF5A were both increased in the colon of Dhpsfl/fl mice infected with C. rodentium compared to control animals (Figure 1a).