EIF5A and malignant colon neoplasm: Moreover, the level of hypusinated EIF5A was also increased in the human colon cancer cell line HCT 116 (Figure 1c,d) and in a human organoid line derived from histologically normal colon tissue (Figure 1e,f) infected by EPEC; EIF5A level was not affected by EPEC infection in these cells (Figure 1c,e).