For example, expression of CD24 could not be detected in follicles of controls but was also undetectable in two TS patients (Fig. 5A); transcripts of NOX4 were present in all follicle preparations but at a higher level in follicles from TS patients compared to controls (Fig. 5B), and expression of TLR1 was readily detectable in follicles of six out of seven TS patients but in only one of the control patients (Fig. 5C). Here, TLR1 is linked to Timothy syndrome.