20.5-Suggestion: Lifelong monitoring (with prompt nephroprotective RAS blockade therapy if microalbuminuria or hypertension develop) could be offered to individuals heterozygous for a single P/LP variant in COL4A3 or COL4A4 or COL4A5 who have donated a kidney, as for all living kidney donors. (Grade D, expert opinion). This evidence concerns the gene COL4A4 and hypertensive disorder.