20.4-Suggestion: Where kidney donation is considered by an individual heterozygous for a single P/LP variant in COL4A3, COL4A4, or COL4A5 aged over 40 years, in the absence of albuminuria or reduced eGFR, a kidney biopsy could be performed to detect evidence of subclinical kidney damage (i.e. scarring greater than what would be normal for their age) that would preclude donation. This evidence concerns the gene COL4A4 and Nephropathy.