found that colorectal cancer patients harboring KRAS-G12D mutations and presenting synchronous metastasis manifest a disease phenotype associated with potentially worse prognostic outcomes.47 Based on prior research and our findings, the identification of KRAS mutations, particularly the G12D subtype, holds significant importance for colorectal cancer patients because of their prognostic value and potential therapeutic implications. The gene discussed is KRAS; the disease is colorectal cancer.