The study consisted of 92 patients (a total of 184 tissues, including 55 colorectal cancer tissue samples, 55 colorectal NAT samples along with blood samples, 37 gastric cancer tissue samples, and 37 gastric NAT samples along with blood samples, with 53 collected from the Golestan Population-based Cancer Registry's biobank and 39 collected from Ayatollah Rouhani Hospital and the Omid Clinic in Babol) with histologically confirmed GI cancer, including 55 men and 37 women, with a mean age of 57 ± 1.2 years. The gene discussed is BRD2; the disease is cancer.