Moreover, multiple meta-analyses have shown associations between the high-risk HPV types 16, 18, 31, 33, and 35 and an increased risk of colorectal cancer.17 It is widely recognized that early proteins of high-risk HPV, including the E5, E6, and E7 oncoproteins, promote cellular alterations, likely contributing to HPV-induced carcinogenesis.18 The notable prevalence of high-risk HPV infection in colorectal tumors, along with evidence of viral genome integration, strongly suggests that HPV could play a role in the development of colorectal cancer.19 This evidence concerns the gene ARHGEF15 and colorectal neoplasm.