The role of TOE1 and HPSE2 in dyslipidemia were also not mentioned in previous studies, with the limited knowledge that TOE1 encodes an unconventional deadenylase and maintains telomerase activity [34], and HPSE2 is determined as the culprit gene for an autosomal recessive disease named urofacial syndrome [35]. This evidence concerns the gene TOE1 and metabolic syndrome.