Intriguingly, common variants of QTRT1 from genome‐wide analysis study (GWAS) in the GLGC were evidenced to influence serum TC and LDL‐C, but in our exome analysis rare mutations of QTRT1 showed significant association with higher levels of TG, implying the complex role of QTRT1 in the lipid metabolism and atherosclerosis, which deserves further research. The gene discussed is QTRT1; the disease is atherosclerosis.