IL11 and craniosynostosis: In this regard, Il6−/− and Il6ra−/− mice show marked differences in wound healing, colitis severity and glucose metabolism, whereas comparisons between Il11−/− and Il11ra−/− mice display phenotypic differences in bone deformities (e.g., craniosynostosis seen in Il11ra−/− mice) and pulmonary fibrosis, which is protected in Il11−/− mice [9, 11].