In PCa, the AR cistrome is distinct and highly associated with motifs for FOXA1 and HOXB13, and these can drive the AR cistrome to reflect PCa3,10–12, while other genomic alterations impair the normal growth suppressive cistrome and transcriptome of AR5, revealing the plasticity and context-dependency of AR programs. This evidence concerns the gene FOXA1 and posterior cortical atrophy.