Similar effects were observed in other androgen-dependent prostate cell lines (LAPC4) and LNCaP/AR cells with higher AR expression levels (Supplementary Fig. 5a–d), but non-prostate cells (293T) and androgen-indifferent PCa cells (PC3, DU145) showed no effect of MACC induction (Supplementary Fig. 5e-g), consistent with lineage specificity. The gene discussed is AR; the disease is posterior cortical atrophy.