M(LPS) SSc hMDMs also exhibited higher levels of pro-inflammatory markers CD86, CD38 and PD-L1 (Supplementary Fig. S5A–D, available at Rheumatology online) and increased secretion of TNF-α and IL-10 (Supplementary Fig. S5E, available at Rheumatology online). The gene discussed is CD274; the disease is systemic sclerosis.