NFKB1 and systemic sclerosis: Time-course experiments (0’, 15’, 30’, 60’) revealed strong activation of NF-κB signalling (Fig. 4C and D, Supplementary Fig. S6, available at Rheumatology online) and increased total NF-κB expression at baseline (0’) in M0 SSc hMDMs compared with controls (Fig. 4E).