These data were confirmed by our results showing that akr1e1, akr1c14 and akr1c20 were the most abundant isoforms expressed in murine brain and, most importantly, that the expression of the three was consistently reduced in tissues exposed to both IFNγ and TNFα, the main pro-inflammatory cytokines associated with MS-dependent neuroinflammation [42]. Here, IFNG is linked to myeloid sarcoma.