This was in striking contrast to reports in CD8+ T cells(13, 15), in which Asn deprivation leads to activation of OXPHOS and increased nucleotide synthesis, associated with enhancement of proliferative capacity and enlarged mitochondrial mass, although others have noted reduction of cell division without Asn in this cell type, and also in cancer cells(12, 14, 44). This evidence concerns the gene CD8A and cancer.