Abnormal synthesis of GSLs mediated by B3GNT5 may alter the glycosylation pattern on tumor cell membranes, subsequently impacting immune cell recognition and function.For example, in pancreatic cancer cell line PANC-1, a decrease in cell self-renewal ability was observed after down-regulation of B3GNT5 expression, indicating the importance of B3GNT5 in maintaining the characteristics of tumor stem cells. The gene discussed is B3GNT5; the disease is familial pancreatic carcinoma.