On the other hand, we observed downregulation of B3GNT5 in five tumors which include breast invasive carcinoma (BRCA), prostate adenocarcinoma (PRAD), skin cutaneous melanoma (SKCM), testicular germ cell tumor (TGCT), and thyroid carcinoma (THCA) (Fig 1A). The gene discussed is B3GNT5; the disease is thyroid gland carcinoma.