GTF2IRD1 encodes DNA binding protein of the Transcription factor (TF) II-I family and its deficiency contributes to neurological deficits of WS patients, such as the impaired motor coordination, visual-spatial constructive deficits and cognitive deficits (Carmona-Mora et al., 2015; Corley et al., 2016; Dai et al., 2009; Enkhmandakh et al., 2009; Kopp et al., 2020; Makeyev and Bayarsaihan, 2009; Morris et al., 2003; O’Leary and Osborne, 2011; Tassabehji et al., 2005). Here, GTF2IRD1 is linked to Werner syndrome.