Nonetheless, hepatic superoxide dismutase (SOD) activity was significantly elevated in both sexes in NASH Slc39a5-/- mice (Figure 6—figure supplement 2E and J), suggesting that the increase in hepatic zinc may be ameliorating the increased hepatic oxidative stress observed in NASH (Friedman et al., 2018). This evidence concerns the gene SOD1 and metabolic dysfunction-associated steatohepatitis.