Furthermore, LOF variation in SLC30A8 (encoding ZnT8, a pancreatic islet zinc transporter) in humans associates with reduced glucose levels and a 65% reduction in T2D risk resulting from enhanced insulin responsiveness to glucose combined with increased pro-insulin processing (Flannick et al., 2014; Dwivedi et al., 2019). The gene discussed is SLC30A8; the disease is type 2 diabetes mellitus.