TNFRSF10A and type 1 diabetes mellitus: In conclusion, autoantibody-positive individuals who lack the two highest-risk HLA DR4-DQ8 and DR3-DQ2 haplotypes are more likely to be older and of non-European ancestry compared with those who have them, and thus may be missed by screening programmes that use these haplotypes or T1D-GRS2, in which DR4-DQ8 and DR3-DQ2 have strong weight.