PLAU and hepatocellular carcinoma: ,7 However, feeding a high-fat diet to major urinary protein-urokinase-type plasminogen activator transgenic mice, which have hepatocyte endoplasmic reticulum stress because of high urokinase-type plasminogen activator expression, induces MASH with HCC,8 indicating that in mice fed a basic high-calorie diet, an additional factor is required to promote MASH and HCC development.