Although c-Fos, c-Jun, and c-Myc expression levels were not elevated in tumor tissues, c-Fos and c-Jun were transiently upregulated in some nontumor tissues from HFHSD-fed DKO mice at week 30 (Figure 7D and Supplemental Figure S7A, http://links.lww.com/HC9/B797). This evidence concerns the gene JUN and neoplasm.