ULK1 and hyperinsulinemic hypoglycemia, familial, 4: In contrast, during nutrient deficiency, a reduction in mTORC1 signaling alleviates the induction complex’s negative inhibition on ULK1/2 and TFEB, allowing autophosphorylation of ATG13 and FIP2000 by ULK1/2 [79,80] and TFEB nuclear translocation for CLEAR gene network expression [89].