The B6.Cg‐Tg(PMP22)C3Fbas/J also known as PMP22‐C3 mice (CMT1A) and the CAST;B6‐GarsNmf249/JRwb CMT2D mice were chosen as models of demyelinating and axonal forms of CMT, respectively. This evidence concerns the gene CAST and Charcot-Marie-Tooth disease.