When we clustered the results, one PPI cluster for LVEF is dominated by genes previously implicated with dilated cardiomyopathy and heart failure risk (HSPB7, FLNC, ALPK3, CLCNKA) (Figure 4A), as well as links to the brain via WDR7391–97. The gene discussed is ALPK3; the disease is dilated cardiomyopathy.