TTN and dilated cardiomyopathy: It is worth noting that FKBP7, PRKRA, and third gene (PLEKHA3, significant with LVM, LVEDV, and LVESV), all lie within a region of chromosome 2 that also includes the gene TTN, which is well established heritable cause of dilated cardiomyopathy, a leading cause of heart failure88–90.