Comparing the genes that were contributing to the estrogen response, we found 23 shared genes between T2D PC3 and ADxT2D PC3 (PDZK1, LLGL2, KLK11, TOP2A, PTGES, FARP1, NAB2, CISH, MEST, KIF20A, LTF, ISG20, IMPA2, DUSP2, PLAC1, PRKAR2B, TNNC1, OPN3, AREG, ATP2B4, AGR2, CALCR, and RABEP1), 2 genes between T2D PC2 and ADxT2D PC3 (DHCR7 and MAPT), 10 genes between T2D PC2 and T2D PC3 (TPBG, FKBP4, GLA, NXT1, CD44, PGR, RAB31, AFF1, TFAP2C, and TJP3), and 5 genes shared across all three mouse PCs (SULT2B1, OVOL2, SIAH2, FDFT1, and RBBP8) (Supplementary Figure S3). Here, PDZK1 is linked to type 2 diabetes mellitus.