Importantly, hnRNPC and hnRNPD levels can be detected in plasma samples and has been found to be significantly reduced in patients with bulbar compared to limb-onset ALS,26 highlighting the need for further investigation into the potential of these hnRNPs to serve as proximal markers of TDP-43 dysfunction and/or disease subtypes, particularly since hnRNPC is already recognized as a promising biomarker in various cancers.27 Here, TARDBP is linked to amyotrophic lateral sclerosis.