GPT and chronic kidney disease: In a clinical trial, it was observed that patients with type 2 diabetes and stage 4 chronic kidney disease had elevated levels of serum liver injury markers, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and γ-glutamyl transferase, after receiving methylprednisolone intervention for 4 weeks (Lewis et al., 2021).