GPX4 and acute respiratory distress syndrome: However, Li et al. (2020b) found that the protective effect of iASPP overexpression on IIR-induced ferroptosis in ALI/ARDS was dependent on the expression of NRF2, which increased the expression of GPX4 as well as HIF-1α, and decreased the expression of ferroptosis-associated proteins FTH1, NQO-1, and HO-1 (Li et al., 2020b).