By promoting the expression of NRF2 or knocking down its negative regulators could reduce the secretion of various cytokines such as TNF-α, IL-1b and IL-6 as well as the production of ROS and MDA, decrease the level of ferrous ions, and increase the expression of SLC 7A 11 and GPX 4 to ameliorate the LPS-induced ferroptosis in ALI, suggesting that the NRF2 signaling pathway plays a critical role in improving the pathogenesis of LPS-induced ferroptosis in ALI (Nishizawa, Yamanaka & Igarashi, 2022; Wang et al., 2023). Here, NFE2L2 is linked to acute respiratory distress syndrome.