The investigators found that OA-induced ALI lung tissue iron concentration was significantly increased, ferritin was decreased, GSH and GPX 4 proteins were decreased, mitochondrial atrophy and mitochondrial membrane rupture were observed in lung cells, as well as an increase in mRNA expression of prostaglandin endoperoxide synthase 2 (PTGS2), which was 7-fold that of the control group (Zhou et al., 2019). The gene discussed is PTGS2; the disease is acute respiratory distress syndrome.