NFE2L2 and cancer: NRF2 activation promotes cell restoration of REDOX and protein homeostasis, protects mitochondrial function, and inhibits inflammation, all processes that contribute to the survival of neurons and astrocytes, perhaps the most suitable disease areas are neurological diseases, as well as metabolic diseases and cancer prevention (Dinkova-Kostova & Copple, 2023; Tebay et al., 2015).