HMOX1 and acute respiratory distress syndrome: In addition, in vitro administration of isoliquiritin apioside (IA) inhibited IIR-induced up-regulation of Hif-1α mRNA as well as protein in ALI/ARDS mice or MEL12 cells and reduced the accumulation of lipid peroxidation products and Fe2+ in IIR-induced lung tissues, suggesting that IA inhibit ferroptosis through the HIF-1α/HO-1 pathway during ALI (Zhongyin et al., 2022).