It was found that regulating the levels of its downstream ferroptosis-related proteins by NRF2 could counteract oxidative stress and attenuate IIR-induced ferroptosis in ALI/ARDS, e.g., NRF2 regulated the levels of SLC7A11, which increased GSH synthesis and enhance the reduction of lipid peroxides by GPX4 (Dong et al., 2020; Dong et al., 2021; Qiang et al., 2020). The gene discussed is NFE2L2; the disease is acute respiratory distress syndrome.