This seems unlikely because no hallmark AD pathological features were observed in CAMKK2 knockout adult mouse brains, although some hippocampus-dependent long-term memory (LTM)-based behaviors, such as spatial memory formation, were affected, while others, such as contextual, trace fear, and passive avoidance, were not (Peters et al., 2003). This evidence concerns the gene CAMKK2 and Alzheimer disease.