When CAMKK2 protein levels in AD and CN patients were plotted based on their age at the time of death, simple linear regression analysis indicated that the variation in cortical abundance of CAMKK2 protein is not significantly associated with age in both CN (CAMKK2 in CN vs. Age: Slope: -9.245, p-value = 0.0929, R-squared = 0.01768) and AD (CAMKK2 in AD vs. Age: Slope: 0.01904, p-value = 0.9601, R-squared = 0.00003497) patients (Figures 6C, D). Here, CAMKK2 is linked to Alzheimer disease.