The reduction in TF and TFRC in AD correlated with a significantly increased iron content in the same tissue compared to CN individuals, suggesting a possible link to the iron dysregulation observed in AD cortices (Damulina et al., 2020; Spotorno et al., 2020; Smith et al., 1997; Kim et al., 2023; Ayton et al., 2020). Here, TFRC is linked to Alzheimer disease.