Additionally it is important to note that CAMKK2 activity can be independently modulated by several upstream kinases, including glycogen synthase kinase 3 (GSK3), cyclin-dependent kinase 5 (CDK5), and cAMP-activated protein kinase A (PKA) (Green et al., 2011; Racioppi and Means, 2012), which have been implicated in an array of neurodegenerative disorders, including AD (Llorens-Martin et al., 2014; Hooper et al., 2008; Kremer et al., 2011), PD (Golpich et al., 2015; Morales-Garcia et al., 2013; Choi and Koh, 2018) and Huntington’s disease (Cheung and Ip, 2012; Kawauchi, 2014). Here, CDK5 is linked to juvenile Huntington disease.