CAMKK2 and Alzheimer disease: The significant reduction in temporal cortical CAMKK2 protein levels of both AD and PD patients compared to CN individuals aligns with previous studies suggesting a critical role for CAMKK2 in brain cells, specifically in neuronal function (Sakagami et al., 2000; Sakagami et al., 1998) and iron homeostasis (Sabbir, 2018; Sabbir, 2020a).