APOE and Alzheimer disease: Additional adjustment for adulthood SES, APOE ε4 status, and childhood IQ at 11 years old resulted in statistically significant associations for the cumulative PM2.5 exposure during 1935–1980, 1935–1990, 1935–2001, and 1935–2007 with the hazard of AD (HR = 1.51, 95% CI = 1.02, 2.21, P = 0.04, PFDR = 0.48; HR = 1.50, 95% CI = 1.02, 2.21, P = 0.04, PFDR = 0.50; HR = 1.50, 95% CI = 1.02, 2.20, P = 0.04, PFDR = 0.52; HR = 1.50, 95% CI = 1.02, 2.20, P = 0.04, PFDR = 0.53) (Appendix Table S7; http://links.lww.com/EE/A315).