Previous research has established a link between hypercortisolism and an enhanced coagulation system, particularly evident in CS, which typically involves an alteration of the intrinsic coagulation pathway, in particular an increase in FVIII, and increased levels of coagulation inhibitors (ie, ATIII, protein C, and protein S) as a compensatory response [22]. The gene discussed is PROS1; the disease is adrenal gland hyperfunction.