CYP11B1 and congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency: In this study, participants 10 and 12 were reported to have uncontrolled hypertension, which can be reported in disorders of steroidogenesis, such as 11-beta-hydroxylase deficiency, caused by biallelic variants in the CYP11B1 gene, a downstream target of FDXR in the adrenal gland.