MYOC and open-angle glaucoma: Of note, both POAG patients with MYOC p.(Cys5Trp) or p.(Thr293Met) variants had severe glaucomatous optic neuropathy (Supplemental Figures 2 and 3), in which p.(Thr293Met) showed protein instability (ΔΔG: −0.120 kcal/mol, Supplemental Figure 3).