Four rare variants: MYOC p.(Cys5Trp), p.(Gly12Arg), p.(Thr256Met), and p.(Thr293Met) were identified within MYOC in the POAG patients, 2 of which, MYOC p.(Cys5Trp) and p.(Thr293Met), were novel and not present in the Japanese-specific reference panel. This evidence concerns the gene MYOC and open-angle glaucoma.