OPTN and open-angle glaucoma: Next, we performed direct sequencing of the OPTN coding region in the POAG patients and found 3 rare variants: OPTN p.(Asn51Thr), p.(Glu135Lys), and p.(Gln142His), 2 of which, OPTN p.(Asn51Thr) and p.(Gln142His), were novel and not in the database.