Given the C-terminal globular region of myocilin contains homology to olfactomedins,32 the MYOC p.(Thr293Met) variant within globular domain identified in this study, similar to other p.(Cys245Tyr), p.(Pro370Leu), and p.(Tyr437His) variants,33 may promote the formation of secretion-incompetent intracellular aggregates, linked to the induction of endoplasmic reticulum stress, thus triggering elevated IOP in POAG. The gene discussed is MYOC; the disease is open-angle glaucoma.