Approximately one-quarter of MS patients were shown to have EBNA1 – GlialCAM (a glial cell adhesion molecule) (12), or EBNA1 – CRYAB (alpha-crystallin B) cross-reactive antibodies (22), while immunizing a mouse with the EBNA-1 promotes CNS inflammation in EAE (experimental autoimmune encephalomyelitis) animal models. This evidence concerns the gene HEPACAM and inflammatory response.