To investigate the relationship between the sensitivity of cancer cells to UNE-C1-induced ICD and the expression levels of TLR2, we selected four distinct human cancer cell lines (AsPC-1, Panc10.05, Caco-2, and HT-1080) with varying TLR2 expression levels based on data from the Cancer Cell Line Encyclopedia (CCLE) (Supplementary Figure 6A). This evidence concerns the gene TLR2 and cancer.