However, the approach of one-size-fits-all cannot be applied to autoimmunity since some autoimmune diseases are characterized by immunoregulatory bystander T cells such as in the case of SLE where activated bystander CD4 T cells expressing NKG2D secrete IL-10 and TGF-β (193). This evidence concerns the gene TGFB1 and systemic lupus erythematosus.