PRF1 and neoplasm: To better address the potential for combination immunotherapy response, we again took advantage of data from the TOPACIO trial and, based on the clinical response, trained a logistic regression model and learned weights for three surrogate variables: MutSig3 as an indicator for BRCAness, average expression of PRF1 and GZMB as indicators for cytolytic activity, and expression of C1QA as an indicator for tumor-associated suppressive macrophages.