LAMP1 and nonpapillary renal cell carcinoma: A comprehensive analysis of the RNA sequencing data from 539 ccRCC patients and 72 normal tissues sourced from the TCGA database revealed a significant decrease in LAMP1 mRNA expression within tumor tissues, both in unpaired samples (n = 611) and paired samples (n = 72) (Figures 2A, B, P<0.001).