Notably, LAMP1 was significantly downregulated in renal cancers, including Kidney Renal Clear Cell Carcinoma (KIRC), Kidney Chromophobe (KICH) and Kidney Renal Papillary Cell Carcinoma (KIRP), as well as lung cancers such as lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). The gene discussed is LAMP1; the disease is lung cancer.