INS and cancer: Pathway analysis of differentially methylated circadian genes linked to HS cases performed with REACTOME revealed enrichment of several prominent canonical cellular pathways, including MAPK signaling pathway, estrogen signaling pathway, oxytocin signaling pathway, WNT signaling pathway, as well as pathways associated with cancer (pancreatic and non-small cell lung cancer), longevity regulation, lysosomes, and insulin secretion (Figure 3).