These observations have stimulated a significant body of research to investigate a broad group of potential biomarkers of SSc, including selectins, immunoglobulin-like cell adhesion molecules, VEGF, endoglin, endothelin-1, pentraxin-3, endostatin, angiostatin, angiopoietins, matrix metalloproteinases, neurovascular guidance molecules, sirtuins, cytokines, adipokines, thrombomodulin, soluble CD163, brain natriuretic peptide, von Willebrand factor, and soluble urokinase plasminogen activator receptor (25). Here, VEGFA is linked to systemic sclerosis.