The prognostic value of these key telomerase genes was explored by univariate COX regression analysis, in which some typical oncogenes, such as HMGB3, XRCC4, RGS3, and PFKL, were found to be positively correlated with the poor prognosis, and some typical tumor suppressor genes, such as JAK2 and DAXX, were also found to be negatively correlated with the poor prognosis in breast cancer patients (Figure 1C). Here, PFKL is linked to breast cancer.