However, interestingly, increasing lines of evidence collected from human and experimental animal studies have shown that ApoL1 G1 and G2 equally contribute to kidney disease in vitro and in vivo, and given the complexity of ApoL1 G1, ApoL1 G2 allele transgenic mouse was largely developed to study the mechanism by which ApoL1 risk allele caused podocytopathy.5 The gene discussed is APOL1; the disease is kidney disorder.