In Chinese males, there is a notable correlation between elevated SUA levels and NAFLD. Moreover, within individuals diagnosed with NAFLD, indicators of liver impairment, such as heightened ALT levels in conjunction with a genetic predisposition (specifically the Met196Arg variant in TNFRSF1B (rs1061622)), are linked to elevated SUA concentrations associated with inflammatory processes (56). This evidence concerns the gene TNFRSF1B and metabolic dysfunction-associated steatotic liver disease.