Conversely, LAM neutrophil phagocytosis-activating antibodies, together with PstS1-specific IgG1 and IgA titers enriched in macaques with breakthrough infections, strongly correlated with a myriad of additional IgG- and IgA-related features such as IgG1 titers across all Mtb antigens evaluated, and Ag85-specific IgA (Figure 4C, right), suggesting that IgG- and IgA-skewed responses expand selectively following breakthrough infection as a consequence of increasing bacterial antigen load. The gene discussed is CD79A; the disease is infection.