The ROC curve analysis for the predictors of severe EM (stage III-IV) on laparoscopy defined high serum CA125 and NLR as the predictors of high significance (p=0.003 & 0.005, respectively), followed by high NPR (P=0.009), high SIRI and SII (p=0.014 & 0.019, respectively) and lastly high neutrophil count (p=0.037) as shown in table 6. The gene discussed is MUC16; the disease is erythema multiforme.