Besides, it does not induce hypoglycemia and it is not associated with increased weight gain.(8) Different from insulin which requires an insulin-antibody complex to cross the placental barrier, metformin can freely traverse the placenta and circulate in the foetus.(9,10) Despite that, there is no evidence of adverse fetal effects or increased risk of major malformations when metformin is used in pregnant women.(8) Patients initiating metformin treatment may experiencing mild gastrointestinal adverse effects. This evidence concerns the gene INS and Hypoglycemia.