We compared the phenotype frequency of variants proximal to the start of the gene overlap (GRCh38, chr4: 5748084), which affect only EVC, and those distal to that position, which affect both EVC and CRMP1. We observed an imbalance toward variants that affected both genes, which were associated with an increased frequency of multiple phenotypes (Figure 4B), including several common skeletal and ectodermal dysplasia findings, with mostly moderate effects (Supplemental Tables 11 and 12). This evidence concerns the gene CRMP1 and ectodermal dysplasia syndrome.