MLKL and Hepatic fibrosis: Guo et al. (2022) demonstrated that MLKL deficiency diminished necroptosis in hepatocytes and curbed the stimulation of HSCs, consequently impeding the progression of liver fibrosis. Zhang et al. (2019) observed significant increases in the expression levels of RIPK3 and MLKL in hepatocytes with O-GlcNAc transferase (OGT) deficiency.