One was a 90-year old male asymptomatic for ALS or FTD, with a distinct ∼70 repeats in blood, no signs of neurodegeneration, overexpression of C9orf72/C9ORF72 and devoid of TDP-43 neuropathology (summarized in Supplementary Table S2). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.