For example, patients with FPLD that simultaneously carries LMNA p.S583L and p.T528M mutations showed a much more severe lipoatrophy than those harboring LMNA p.S583L only, while carriers of p.T528M variant do show not lipodystrophy at all (Savage et al., 2004). Here, LMNA is linked to familial partial lipodystrophy.