Congenital generalized lipodystrophy (CGL) is the most extreme form of human genetic leanness and is caused by homozygous pathogenic variants in the AGPAT2, BSCL2, CAV1, or PTRF (CAVIN1) genes (Cortés et al., 2014; Cortés et al., 2009; Santos and Cortés, 2021). This evidence concerns the gene CAVIN1 and congenital generalized lipodystrophy.