Patients with less frequent LMNA variants (p.R644C, p.R582H, p.R582C, p.T528M, p.N466D, p.D47N, p.R471G) are referred to as having an “atypical” FPLD and show a milder phenotype (Fernandez-Pombo et al., 2023a; Araújo-Vilar et al., 2021). The gene discussed is LMNA; the disease is familial partial lipodystrophy.