LMNA and lipodystrophy: Although single de novo pathogenic variants have been previously reported in two patients with a neonatal-onset type of lipodystrophy (Garg, 2011), the case described herein is appealing from a genetic standpoint because it occurs with two de novo pathogenic variants separated by only 17 nucleotides within exon 8 of the LMNA gene (5 amino acid residues in the lamin A/C protein).