In breast cancer, HER2 interacts with ETV1 to synergistically activate the transcription of hTERT, making breast cancer more invasive; ETV1 can also coordinate with HER2/Neu to upregulate the expression of Rcl, and the combination of ETV1 and the Rcl is related with later tumor staging [43]. The gene discussed is ERBB2; the disease is breast carcinoma.