In evaluating the prognostic significance of RRGS for colorectal cancer patients, we observed distinct expression levels of the model genes AKAP12, CAV2, CCL11, CPE, FAM3B, L1TD1, MAGEA6, MMP3, SERPINE1, SFRP2, and STC1, along with survival status and duration in RRGS-Low and RRGS-High subtypes (Figure 3E). The gene discussed is SFRP2; the disease is colorectal cancer.