Our results revealed that 15 pathways, including the interferon gamma response, IL-6/JAK/STAT3 signaling pathway, and Epithelial-mesenchymal Transition (EMT), were significantly activated in GBM patients with RAB32 overexpression (NES > 1.5, FDR < 0.25, and p < 0.001). The gene discussed is STAT3; the disease is glioblastoma.