Our results revealed that the high expression of PPP1R14B might lead to a decrease in CD40 through direct regulation or possible ALKBH2/UCK2-NF-κB-CD40 signaling, thereby hindering differentiation of B cells and formation of plasma cells, which resulted in insufficient expression of antibodies and strength frustration of humoral immunity directed against PCa. This evidence concerns the gene NFKB1 and posterior cortical atrophy.