Our results revealed that the high expression of PPP1R14B might lead to a decrease in CD40 through direct regulation or possible ALKBH2/UCK2-NF-κB-CD40 signaling, thereby hindering differentiation of B cells and formation of plasma cells, which resulted in insufficient expression of antibodies and strength frustration of humoral immunity directed against PCa. The gene discussed is ALKBH2; the disease is posterior cortical atrophy.