In summary, overexpression of PPP1R14B could result in the upregulation of ALKBH2, UCK2, RAC3 and RAB17 and downregulation of CD40, DKK3, COL17A1 and PGRMC1, which would stifle humoral immunity against PCa through declining the level of plasma cells, block cellular immunity based on NK and CD8+ T cells by upregulating Tregs, destroy cellular immunity according to macrophages via increasing the proportion of M2 macrophages and repress cellular immunity based on neutrophils by means of blocking neutrophil chemotactic activity conclusively inhibiting adaptive immune directed against PCa. Here, PGRMC1 is linked to posterior cortical atrophy.