Subsequently, multivariate COX analysis was performed by combining gleason grade with PPP1R14B, and the results revealed that PPP1R14B (p<0.05, HR: 3.31, 95% CI: 1.2-9.4) and gleason grade (p<0.05, HR: 2.81, 95% CI: 12.2-6.3) (Fig. 7b) had independent prognostic value for overall survival of PCa. Here, PPP1R14B is linked to posterior cortical atrophy.