FGF5 and hepatocellular carcinoma: FGFBP1 could enhance FGFR signaling pathway by releasing FGF5 and FGF12 from the extracellular matrix which were verified by the RNAseq data 25-27, ERK was the main downstream effector of FGFR signaling pathway, we proposed that SETD2 promoted proliferation and migration of HCC cells through ERK, so we also assessed the ERK phosphorylation level of HCC cells by western blotting; the results (Figure 4I) showed that SETD2 overexpression could enhance ERK phosphorylation level and SETD2 silencing could decrease ERK phosphorylation level in BEL-7402 cells.