In this work, we evaluated the function and mechanism of SETD2 in HCC through bioinformatics analysis and cell experiments, and our findings highlighted the promoting role of SETD2 in HCC cell proliferation and migration, which will guide further studies about the role of SETD2 and FGFBP1 in HCC tumorigenesis and progression. This evidence concerns the gene FGFBP1 and hepatocellular carcinoma.