SETD2 and hepatocellular carcinoma: Subsequently, we assessed the impact of SETD2 silencing on the proliferation of HCC cell lines via CCK-8 assays, and the results showed that the proliferation ability of BEL-7402 cells was decreased upon si-SETD2-03 transfection but not upon si-SETD2-02 transfection (Figure 2C).