SETD2 and hepatocellular carcinoma: To further investigate whether SETD2 affects the proliferation and migration of HCC cell lines, we constructed vectors encoding amino acids 1-952 (aa), 953-1734 aa (containing the SET domain) and 1735-2565 aa of SETD2 and defined them as SETD2-F1, SETD2-F2, and SETD2-F3, respectively (Figure 3A).