Meanwhile, a chi-squared test used to analyze the relationship between the YAP expression and clinicopathological characteristics of patients with CRC indicated that YAP expression correlated with lymph node metastasis, venous invasion, and TNM staging but not with age, gender, tumor size, depth of tumor invasion, degree of differentiation, and neural invasion (Table 1). Here, YAP1 is linked to metastatic malignant neoplasm in the lymph nodes.